PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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cis-Ethyl 2-(4-aminocyclohexyl)acetate hydrochloride
0 ImagesCat. No.: HY-W582038CAS No.: 76308-13-9
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BnO-PEG2-Br
0 ImagesCat. No.: HY-W346199CAS No.: 121537-55-1
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13-((tert-Butoxycarbonyl)amino)tridecanoic acid
0 ImagesCat. No.: HY-W883157CAS No.: 1661040-67-0
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Propargyl-PEG1-NH2 hydrochloride
0 ImagesCat. No.: HY-W140808CAS No.: 1383604-96-3
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2-(but-3-yn-1-yloxy)ethan-1-amine
0 ImagesCat. No.: HY-W096108CAS No.: 122116-14-7
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tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate dihydrochloride
0 ImagesCat. No.: HY-W380469CAS No.: 686298-02-2
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Pentane-1,5-dithiol
0 ImagesCat. No.: HY-W195463CAS No.: 928-98-3
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cis-3-(Aminomethyl)cyclobutanol hydrochloride
0 ImagesCat. No.: HY-21369CAS No.: 1400744-20-8
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DBCO-PEG5-GGG-NH2
0 ImagesCat. No.: HY-W1130362CAS No.: 2762519-06-0
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Ethyl 3-(N-BOC-piperidin-4-yl)propioate
0 ImagesCat. No.: HY-W001528CAS No.: 301232-45-1
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Tetracosanedioic acid
0 ImagesCat. No.: HY-W451467CAS No.: 2450-31-9
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trans-3-(Aminomethyl)cyclobutanol hydrochloride
0 ImagesCat. No.: HY-W055967CAS No.: 1404365-04-3
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Hydroxy-PEG4-NH-CO-OBn
0 ImagesCat. No.: HY-W544848CAS No.: 2060574-09-4
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Boc-PEG2-but-1-yne
0 ImagesCat. No.: HY-W981123CAS No.: 2568607-37-2
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PEG3-bis(carbonochloridic acid)
0 ImagesCat. No.: HY-W881485CAS No.: 17134-17-7
